Please read this information before you start taking XENICAL and each time you renew
your prescription. This important information may help you successfully lose weight and
maintain your weight loss while taking XENICAL. This patient information is a
summary and is not intended to take the place of discussions with your doctor. It does not
list all benefits and risks of XENICAL.

What is XENICAL?
XENICAL is an oral prescription weight loss medication used to help obese people lose
weight and keep this weight off. XENICAL works in your intestines, where it blocks
some of the fat you eat from being absorbed. This undigested fat is then eliminated in
your bowel movements. XENICAL should be used together with a reduced-calorie diet
that your doctor will recommend.

1. Excess weight has been proven to contribute to an increased risk of developing many

medical problems, including high blood pressure, high cholesterol, heart disease, and
diabetes. The consumption of excess fatty food and calories plays a significant role in the
development of excess weight. While fat is an important component of a balanced diet,
the consumption of excess fat contributes to excess body weight, since fat provides twice
the number of calories per gram of weight as carbohydrates and protein. Reduction of
dietary fat intake is one potential way of losing weight.

How does XENICAL work?
If you eat an excess amount of fat or calories, the excess is stored as fat by the body
resulting in weight gain. When you eat fat, your body breaks it down into its simplest
components so that it can be absorbed. Enzymes in your intestinal tract, called lipases,
help digest (or break down) fat. When you take XENICAL with meals, XENICAL
attaches to the lipases and blocks them from breaking down some of the fat you have
eaten. The undigested fat cannot be absorbed and is eliminated in your bowel
movements. By working this way, XENICAL helps block about 30% of the fat eaten in
food from being absorbed by your body.

Information for adolescent obese patients

Following one year of treatment, XENICAL in combination with diet was shown to be
more effective in reducing Body Mass Index (BMI) than diet alone. A reduction in Body
Mass Index is a better indicator of weight loss in children because it takes into account
changes in weight related to growing children.

Information on how to lose weight for adult obese patients

Following one year of treatment, XENICAL in combination with diet was shown to be
more effective in reducing weight than diet alone. In most cases, weight loss was gradual.
Patients treated with XENICAL and a reduced-calorie diet for one year lost an average of
13.4 pounds while those on a reduced-calorie diet alone lost 5.8 pounds.